Two college girls, traveling the famous Train 8 from Seattle to Chicago, find themselves at the center of an experimental GMO virus outbreak that causes passengers to turn into blood thirsty primordials. The surviving girls and a handful of passengers are faced with the moral dilemma of stopping the train to save themselves - and let the deadly virus infect the world - or keep the train running, buying more time until help comes but only if they can survive the killing horde of the Infected.